Pengaruh Pemberian Streptozotocin Dosis Tunggal terhadap Kadar Glukosa Tikus Wistar (Rattus norvegicus)

Nihayah Enis Munjiati

Abstract


Diabetes Mellitus (DM) is a disease caused by metabolic disorders in the pancreas, which is characterized by an increased glucose levels or hyperglycemia due to decreased insulin levels from the pancreas. In animal research, DM is often caused by administration of diabetogenic agents. Streptozotocin works by forming free radicals that can damage the pancreatic beta cells; therefore, insulin production can be disrupted. This study aims to determine the glucose level on Wistar Rats (Rattus norvegicus) before and after a single dose streptozotocin-induced. This study was conducted experimentally with a posttest-interpretation design with a control group design. The result demonstrated that the average blood glucose level before the induction of streptozotocin was 92,63 (SD 10,487) mg/dL, after being induced by streptozotocin was 235,56 (SD 164,929) mg/dL with a difference of 142,938 (SD 160,543) mg/dL. In this study, it can be concluded that the induction of a single dose of streptozotocin has an effect on increasing blood glucose levels on Wistar Rats (Rattus norvegicus).


Keywords


blood glucose, diabetes mellitus, streptozotocin, wistar rats

Full Text:

PDF

References


Isnaini N, Ratnasari R. Faktor Risiko Mempengaruhi Kejadian Diabetes Mellitus Tipe Dua. Jurnal Kebidanan dan Keperawatan Aisyiyah 2018, 14(2): 59-68.

International Diabetes Federation. IDF Diabetes Atlas. 9th Edition. International Diabetes Federation; 2019.

Kementrian Kesehatan RI. Riset Kesehatan Dasar (Riskesdas) 2018. Jakarta: Badan Penelitian dan Pengembangan Kementrian Kesehatan; 2018.

Saputra N., Suartha I., dan Dharmayudha A. Agen Diabetagonik Streptozotocin untuk Membuat Tikus Putih Jantan Diabetes Mellitus. Buletin Veteriner Udayana 2018, 10(2): 116-21.

Husna F., Fransciscus D., Wawaimuli A., dan Erni H. Model Hewan Coba pada Penelitian Diabetes. Pharmaceutical Sciences and Research 2019, 6(3): 131-41.

McNeill J. Experimental Models of Diabetes. Florida: CRC Press; 2018.

Caple C. Blood Glucose Testing: Using a Venous Blood Sample [Internet]. Ebscohost.com. 2014

[cited 6 Aug 2020]. Didapat dari: URL: https://www.ebscohost.com/images-nursing/assets/BloodGlucoseTestingUsingVenousBlood.pdf

Colby L., Nowland M., and Kennedy L. Clinical Laboratory Animal Medicine: An Introduction. Hoboken: Wiley-Blackwell; 2019.

Rosyadi I., Romadhona E., Utami A., Hijrati Y., dan Santosa C. Gambaran Kadar Gula Darah Tikus Wistar Diabetes Hasil Induksi Streptozotocin Dosis Tunggal. ARSHI Veterinary Letters 2018, 2(3): 41-2.

Firdaus R., Sri A., dan Katrin R. Model Tikus Diabetes yang Diinduksi Streptozotocin-Sukrosa untuk Pendekatan Penelitian Diabetes Melitus Gestasional. Jurnal Media Kesehatan Masyarakat Indonesia 2016, 12(1): 29-34.

Lenzen S. The Mechanism of Alloxan and Streptozotocin Induced Diabetes. Journal Diabetologia 2008, 51(2): 216-226.

Kendran A., Sudisma I., Sulabda I., Gorda I., Anggreni L., dan Loekali B. Kadar Glukosa Anjing Kintamani. Bulletin Veteriner Udayana 2013, 5(2): 79-86.

Szkudelski T. The Mechanism of Alloxan and Streptozotocin Action in B Cells of The Rat Pancreas. Physiological Research 2001, 50(6): 537-46.

Greenspan F., dan Baxter J. Endokrinologi Dasar dan Klinik. Jakarta: EGC; 2007.

Furman B. Streptozotocinâ€Induced Diabetic Models in Mice and Rats. Current Protocols in Pharmacology 2015, 5(47): 1-20.

Deeds M., Anderson J., Armstrong A., et al. Single Dose Streptozotocin-Induced Diabetes: Considerations for Study Design in Islet Transplantation Models. Laboratory Animals Science Association 2011, 45(3): 131-40.




DOI: https://doi.org/10.33992/m.v9i1.1330

Refbacks

  • There are currently no refbacks.


Meditory

POLTEKKES KEMENKES DENPASAR
Address: Jl. Sanitasi No.1, Sidakarya, Denpasar Selatan, Kota Denpasar, Bali 80224 (0361) 710447