THE EFFECT OF VITAMIN A TREATMENT ON RENAL GLOMERULAR AREA OF RATS MODEL DIABETES MELLITUS TYPE 2

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DOI:

https://doi.org/10.33992/meditory.v13i1.3955

Abstract

Background:  Diabetes mellitus (DM) type 2 is a metabolic disorder due to defects in insulin secretion. A microangiopathy complication of DM in the kidney can lead to renal enlargement. This augmentation in renal size can be attributed to several factors, including glomerular hypertrophy, tubular hypertrophy, and interstitial expansion. Retinoic acid, a vitamin A derivative, serves numerous cellular roles, including the induction of cell differentiation, the regulation of apoptosis, and exhibiting anti-inflammatory and antifibrotic properties.

Objective: This study aims to evaluate the effect of vitamin A administration on the renal glomerular area in a rat model of type 2 diabetes mellitus.

Methods: This study was experimental with five groups, including a negative control group, a positive diabetes mellitus group, and three groups of vitamin A treatment. The primary variable assessed was the glomerulus area across the different groups.

Results: No significant decrease in glomerular area was observed in the vitamin A treatment group within the positive diabetes (ANOVA, p = 0.052).

Conclusions: The findings of this study suggest that the administration of vitamin A does not significantly affect the reduction of renal glomerular area in rats with diabetes mellitus.

Author Biographies

Made Dinda Pratiwi, Medical Faculty of Ganesha University of Education

Biomedic department

Prasetyo Adi, Faculty of Medicine Brawijaya University

Biochemistry Department

Kenty Wantri Anita, Faculty of Medicine Brawijaya University

Anatomical Pathology

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Published

2025-06-22

Issue

Vol. 13 No. 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025

Section

Research Articles

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