UJI EFEKTIVITAS EKSTRAK RIMPANG LENGKUAS MERAH (Alpinia Purpurata K. Schum) TERHADAP Candida albicans

Abstract

Background: Infectious diseases are diseases caused by the entry and breeding of microorganisms, namely bacteria, viruses, fungi, prions and protozoa into the body, causing organ damage. Candidiasis is a disease caused by the fungus Candida albicans, commonly found in the skin, mucous membranes and digestive tract. Infection control usually uses antibiotics, but continuous use can lead to resistance to microbes, the use of alternative  materials  is  needed.  Red  galangal  is  one  type  of  spice  that  has  been  widely  used  as  a phytopharmaceutical  product  or  a  product  that  utilizes  vegetable  resources  as  a  source  of  medicinal ingredients. Aim: The purpose of the research was to determine the effect of red galangalrhizome extract on the  growth  of  Candida  albicans. Methods: The  methods  used  are  experimental  and  disc  diffusion  method. Based on the results of the study, it can be seen that there is an inhibitory response seen from the difference in  the  distance  of  theinhibition  zone  between  the  negative  control  and  several  other  concentrations. Resulsts:The results of the measurement of the inhibition of Candida albicans using concentrations of 10%, 20%,  40%,  and  60%  respectively  11.3  mm,  13  mm,  13.3  mm,  14.3  mm.  positive  control  (ketoconazole) formed  an  inhibition  zone  diameter  of  8.6  mm  while  negative  control  did  not  form  an  inhibition  zone. Conclusion: Based  on  the  results  of  the  study,  it  can  be  concluded  that  the  red  galangal  rhizome  extract (Alpinia purpurata K.Schum) has the ability as an antifungal against the growth of Candida albicans.