Relationship between birth weight and gestational age with the incidence of neonatal hyperbilirubinemia
DOI:
https://doi.org/10.33992/jik.v14i2.5093Keywords:
Birth weight, hyperbilirubinemia, neonate, gestational ageAbstract
Hyperbilirubinemia ranks fifth among causes of neonatal morbidity in Indonesia, with most babies born under 35 weeks of gestation and with low birth weight (LBW). Untreated hyperbilirubinemia can lead to kernicterus and neurological disorders. This study aimed to determine the relationship between birth weight and gestational age with hyperbilirubinemia. This study used a cross-sectional approach. Secondary data were collected from 50 infants using total sampling from 50 infants at Denpasar Women's and Children's Hospital (RSIA) during January-December 2024. Data were analyzed univariately using descriptive analysis and bivariately using the Spearman rank test because the data were not normally distributed. The results show that there was a relationship between birth weight and hyperbilirubinemia (p < 0.001), (r = -0.727). There was a relationship between gestational age and hyperbilirubinemia (p < 0.001) (r = -0.857). Midwives need to strengthen collaboration with pediatricians in monitoring bilirubin levels, especially in low-birth-weight and premature infants. In addition, parental education on adequate breastfeeding (8–12 times/day) is essential to promote bilirubin excretion.
References
1. World Health Organization. Newborns: improving survival and well-being. Geneva; 2020 Sep.
2. Blencowe H, Krasevec J, de Onis M, Black RE, An X, Stevens GA, et al. National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis. Lancet Glob Health. 2019;7(7):e849–60. doi:10.1016/S2214-109X(18)30565-5.
3. UNICEF. Low birthweight. 2023 Jul.
4. Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. N Engl J Med. 2008;358(9):920–8. doi:10.1056/NEJMct0708376.
5. Rennie J, Burman-Roy S, Murphy MS. Neonatal jaundice: summary of NICE guidance. BMJ. 2010;340:c2409. doi:10.1136/bmj.c2409.
6. Dennery PA, Seidman DS, Stevenson DK. Neonatal hyperbilirubinemia. N Engl J Med. 2001;344(8):581–90. doi:10.1056/NEJM200102223440807.
7. Watchko JF, Tiribelli C. Bilirubin-induced neurologic damage: mechanisms and management approaches. N Engl J Med. 2013;369(21):2021–30. doi:10.1056/NEJMra1308124.
8. Olusanya BO, Teeple S, Kassebaum NJ. The contribution of neonatal jaundice to global child mortality: findings from the GBD 2016 study. Pediatrics. 2018;141(2). doi:10.1542/peds.2017-1471.
9. Shapiro SM. Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND). J Perinatol. 2005;25(1):54–9. doi:10.1038/sj.jp.7211157.
10. Uria-Avellanal C, Marlow N, Rennie JM. Outcome following neonatal seizures. Semin Fetal Neonatal Med. 2013;18(4):224–32. doi:10.1016/j.siny.2013.01.002.
11. Mojtahedi SY, Izadi A, Seirafi G, Khedmat L, Tavakolizadeh R. Risk factors associated with neonatal jaundice: a cross-sectional study from Iran. Open Access Maced J Med Sci. 2018;6(8):1387–93. doi:10.3889/oamjms.2018.319.
12. Good WV, Wong RJ, Norcia AM, Stevenson DK, Slagel T, Hou C, et al. Bilirubin-induced neurotoxicity and visuocortical dysfunction. J Perinatol. 2023;43(2):240–1. doi:10.1038/s41372-022-01417-2.
13. Hasenstab KA, Jadcherla SR. Evidence-based approaches to successful oral feeding in infants with feeding difficulties. Clin Perinatol. 2022;49(2):503–20. doi:10.1016/j.clp.2022.02.004.
14. Yang YK, Lin CF, Lin F, Chen ZK, Liao YW, Huang YC, et al. Etiology analysis and G6PD deficiency for term infants with jaundice in Yangjiang of western Guangdong. Front Pediatr. 2023;11. doi:10.3389/fped.2023.1201940.
15. Gerungan GP, Wilar R, Mantik MFJ. Mekanisme terjadinya hiperbilirubinemia pada bayi berat lahir rendah. e-CliniC. 2022;11(1):80. doi:10.35790/ecl.v11i1.37828.
Downloads
Published
Issue
Section
Citation Check
License
Copyright (c) 2026 Made Christina Adriani, Gusti Ayu Tirtawati, Ni Made Dwi Purnamayanti, Ni Putu Witha Rahayuni

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with Jurnal Ilmiah Kebidanan (The Journal of Midwifery) retain the copyright of their work and grant the journal the right of first publication.
The article is simultaneously licensed under the Creative Commons Attribution-ShareAlike 4.0 International License, which permits others to share, copy, distribute, and adapt the work for any purpose, provided that appropriate credit is given to the author(s) and the original publication in this journal is acknowledged.
Authors may enter into separate, additional contractual arrangements for the non-exclusive distribution of the published version of the article (for example, posting it to an institutional repository or including it in a book), provided that the original publication in this journal is properly acknowledged.
Authors are also permitted and encouraged to post their work online (for example, in institutional repositories or on personal websites) before and during the submission process. This practice can facilitate scholarly exchange and may lead to earlier and increased citations of the published work.

