THE EFFECT OF CHEMOTHERAPY ON BLOOD CELL COUNTS IN POST-MASTECTOMY BREAST CANCER PATIENTS

Muhammad Haerunnizam; Pancawati Ariami; Thomas Tandi Manu; Lale Budi Kusuma Dewi

doi:10.33992/meditory.v13i2.4096

Authors

Muhammad Haerunnizam Poltekkes Kemenkes Mataram, Indonesia https://orcid.org/0009-0001-3644-3917
Pancawati Ariami Poltekkes Kemenkes Mataram, Indonesia https://orcid.org/0000-0001-6520-0984
Thomas Tandi Manu Poltekkes Kemenkes Mataram, Indonesia
Lale Budi Kusuma Dewi Poltekkes Kemenkes Mataram, Indonesia https://orcid.org/0000-0002-2442-0638

DOI:

https://doi.org/10.33992/meditory.v13i2.4096

Abstract

Background:Â Post-mastectomy chemotherapy often causes myelosuppression, as do the numbers of erythrocytes, leukocytes, and platelets.

Objective:Â To determine the effect of chemotherapy on the number of blood cells in post-mastectomy breast cancer patients.

Methods:Â This study was a retrospective observational study. The population in the study was breast cancer patients who underwent chemotherapy Â 0 (Pre-chemotherapy) to 4 times after mastectomy at the NTB Provincial Hospital from January to December 2024. Sampling was done using non-probability sampling with a purposive sampling method, resulting in 68 samples.

Results:Â In the study, the average number of erythrocytes from session 0 (Pre-chemotherapy) to session 4 was 4,23; 3,80; 3,67; 3,59, and 3,6 million cells/ÂµL. Then, the average number of leukocytes from session 0 (Pre-chemotherapy) to session 4 was 7,208; 5,024; 4,739; 3,690, and 3,281 thousand cells/ÂµL. Meanwhile, the average number of platelets from session 0 (Pre-chemotherapy) to session 4 was 386,251; 302,792; 275,760; 228,014, and 206,035 thousand cells/ÂµL. Based on the Friedman test data analysis, the results showed a significance value of 0.001 < 0.05.

Conclusions:Â There is an effect of chemotherapy on the number of blood cells in post-mastectomy breast cancer patients.

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