THE EFFECT OF CHEMOTHERAPY ON BLOOD CELL COUNTS IN POST-MASTECTOMY BREAST CANCER PATIENTS

Muhammad Haerunnizam, Pancawati Ariami, Thomas Tandi Manu, Lale Budi Kusuma Dewi

Abstract


Background: Post-mastectomy chemotherapy often causes myelosuppression, as do the numbers of erythrocytes, leukocytes and platelets. Aims: To determine the effect of chemotherapy on the number of blood cells in post-mastectomy breast cancer patients. Method: This study was a retrospective observational study. The population in the study were breast cancer patients who underwent chemotherapy  0 to 4 times after mastectomy at the NTB Provincial Hospital from January to December 2024. Sampling was done using non-probability sampling with a purposive sampling method and obtained 68 samples. The results: In the study, the average number of erythrocytes from session 0 to session 4 was 4,23; 3,80; 3,67; 3,59 and 3.6 million cells/µL. Then, the average number of leukocytes from session 0 to session 4 was 7.208; 5.024; 4.739; 3.690 and 3,281. Meanwhile, the average number of platelets from session 0 to session 4 was 386.251; 302.792; 275.760; 228.014 and 206.035. Based on the results of data analysis using the Friedman test, the results showed a significance value of 0.000 < 0.05. Thus, chemotherapy has a significant effect in the form of a decrease in the number of blood cells (erythrocytes, leukocytes, and platelets) in post-mastectomy breast cancer patients. Conclusions: There is an effect of chemotherapy on the number of blood cells in post-mastectomy breast cancer patients.


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DOI: https://doi.org/10.33992/meditory.v13i2.4096

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