ASSOCIATION BETWEEN FASTING GLUCOSE AND C-REACTIVE PROTEIN AS A PREDICTOR FOR DIABETIC STATE

Luh Ade Wilan Krisna

Abstract


Diabetes mellitus (DM) is characterized by elevated blood glucose levels resulting from decreased insulin secretion by pancreatic beta cells. Fasting blood glucose (FBG) measurement is commonly used to monitor DM, requiring patients to fast for a minimum of eight hours. Insufficient insulin production impairs glucose uptake into body tissues, leading to hyperglycemia. Chronic hyperglycemia subsequently stimulates the production of inflammatory cytokines, which promotes the hepatic synthesis of c-reactive protein (CRP). This study aims to determine the relation between FBG levels and CRP levels in patients with diabetes mellitus at Rumah Sakit Daerah Mangusada. An observational analytic study with a cross-sectional design was conducted using purposive sampling, with a total sample of 25 DM patients at Rumah Sakit Daerah Mangusada. Data were analyzed using the Shapiro-Wilk test for normality and the Spearman's rank for correlation test. The analysis that has been carried out on the Shapiro-Wilk, obtained a sig. (2 tailed) 0.012 which means 0.012 < 0.05 and correlation coefficient is 0.493. Persistent hyperglycemia in diabetes mellitus patient induces pro-inflammatory cytokines that stimulate hepatic CRP synthesis. Elevated CRP reflects systemic inflammation, oxidative stress, and tissue injury, which accelerate metabolic damage and vascular complications such as atherosclerosis and coronary artery disease, establishing CRP as a reliable predictor of diabetes-related complications. It can be concluded that has a positive relation with a moderate correlation between blood glucose levels and CRP levels in diabetic patients at Rumah Sakit Daerah Mangusada

Keywords


C-Reactive Protein; Fasting Glucose; Diabetes Mellitus

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References


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DOI: https://doi.org/10.33992/icmahs.v3i1.4738

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