METRONIDASOL SEBAGAI SALAH SATU OBAT PILIHAN UNTUK PERIODONTITIS MARGINALIS

Regina Tedjasulaksana

Abstract


Marginal periodontitis is one of the periodontal diseases which is characterized by the presence of periodontal pockets and tooth mobility. The most predominant bacteria in periodontal disease are anaerobic gram-negative rods such as Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia and Bacteroides forsythus. Metronidazole is an bacteriocidal antibiotic that can be used to treat periodontitis because it can suppress the growth of Actinobacillus actinomycetemcomitans. Periodontal disease also involves aerobic bacterial infection, so the combination of metronidazole and amoxicillin is required in marginal periodontitis therapy. Both of these antibiotics also produce a synergistic effect because amoxicillin can increase the absorption of metronidazole so the concentration becomes higher in the gingival sulcus fluid and can reach the limit of MIC (minimum inhibitory concentration).

Keywords


metronidazole, marginal periodontitis

References


Putri M.H, Herijulianti E, Nurjanah N, Ilmu Pencegahan Penyakit Jaringan Keras dan Jaringan Pendukung Gigi. Jakarta: EGC, 2011.

World Health Organization, Oral Health , diakses tanggal 13 Jan 2016 , tersedia di http://www.who.int / media centre

Martinez, B., Ruiz, F. 2005. Periodontal disease as bacterial infection.Accessed diakses tanggal 14 Januari 2016, tersedia di : scielo.isciii.es/pdf/peri/v17n3/111peri odontal.pdf

Wolf , H.F., Retetschack, E.M., Hasel, T.M. 2004. Periodontology. 3 rd ed. NewYork : Thieme

Coventry, J., Griffiths.G., Scully, C., Tonetti, M. 2000. Periodontal Disease..diakses tanggal 12 Oktober 2011, tersedia di http://www.ncbi nlm.nih.gov/pmc/articles/PMC11276 86/

Ronderos M, Jacobs DR, Himes JH, Pihlstrom B, Krall EA, Garcia RI, Dawson-Hughes B. Periodontal risk assessment, diagnosis and treatment planning. Periodontology 2000, 2001;25(1):37-58.

Brunton,L., Parker,K., Blumenthal, D., Buxton,I., 2011, Manual Farmakologi dan Terapi, EGC, Jakarta

Van Winkelhoff AJ , Tijhof CJ , de Graaff J. Microbiological and clinical results of metronidazole plus amoxicillin therapy in actinobacillus actinomycetemcomitans associated

periodontitis. Journal of periodontology 1992 ; 63 : 52-57

Seiler J S , Herold R W. The use of systemic antibiotics in the treatment of aggressive periodontal disease. Journal of General Dentistry 2005;155-159.

Lofmark, S., Edlund, C., Nord, C.E. 2010. Metronidazole Is Still the Drug of Choice for Treatment of Anaerobic Infections, diakses tanggal 17 Desember 2015, tersedia di :http://cid.oxfordjournals.org/cont ent/50/Supplement_1/S16.full.

Pejcic, A., Kesic, L.,Obradovic, R., Mirkovik, D. 2010. Antibiotics in the Management of Periodontal Disease, diakses tanggal 16

Desmber 2015, tersedia di http://www.medfak.ni.ac.rs/Acta %20facultatis/2010/2-2010/6%20Ana%20Pejcic.pdf. Jurnal Kesehatan Gigi Vol. 4 No. 1 (Pebruari 2016) 22

Tracy,J.W., Webster, L.T., 2008, Obat yang digunakan dalam kemoterapi infeksi protozoa dalam Goodman & Gilman Dasar Farmakologi Terapi. Volume 2, edisi 10. Jakarta : EGC

Tan, H.T., Rahardja, K., 2003. Obat-Obat Penting. Edisi V. Jakarta : Elex Media Komputindo.

Tracy, J.W., Webster, L.T., 2008, Obat yang digunakan dalam kemoterapi infeksi protozoa dalam Goodman & Gilman Dasar Farmakologi Terapi. Volume 2, edisi 10. Jakarta : EGC.

Slots, J. 2002. Selection of antimi-crobial agents in periodontal therapy. Diakses tanggal 14 Januari 2015, tersedia di http://www.carifree. com/

dentists/ documents/02 antimicrobial agents. pdf.

Lopez,N.J.,Socransky, S.S, Da Silva, I., Japlit, M.R., Haffajee, A.D. 2006. Effects of Metronidazole plus Amoxicillin as the Only Therapy on the Microbiological and Clinical Parameters of Untreated Chronic Periodontitis.Diakses tanggal 12 Desember 2015, tersedia di http://www.ncbi.nlm.nih.gov/pubme d/16856904




DOI: https://doi.org/10.33992/jkg.v4i1.503

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